PACT Sponsored Projects

Waisman offers the experience, resources, and guidance to move therapies into clinical trials.  Under PACT, we had several projects at various points on the research-to-clinic development continuum. Waisman's role was to provide translational process development and regulatory support, as well as manufacture clinical grade products for projects as they moved towards the clinic. The PACT program ended on January 14, 2015 but we anticipate several of these projects to continue with alternative funding.

PACT Projects 2010-2015

Exosome-like Microvesicles (MEX) from human bone marrow-derived MSCs -- Stella Kourembanas, MD (Boston Children's Hospital)

Human iPS cell-derived neural retinal cells (hiPSC-NRCs) -- David Gamm, MD, PhD (UW-Madison, Waisman Center)

Production and Expansion of a Human Cardiac Fibroblast (CF) Cell Bank and the Manufacture of CF-Derived Extra-Cellular Matrix (CF-ECM) for Pre-clinical Studies -- Amish Raval, MD (UW-Madison, UWHC)

Ex-vivo Expansion of NK cells using K562 to Treat Neuroblastoma -- Ken DeSantes, MD (UW-Madison, American Family Children's Hospital)

Cell-based Therapy Using MSCs to Treat Obliterative Bronchiolitis (OB) or Bronchiolitis Obliterans Syndrome (BOS)-- Abba Zubair, MD (Mayo Clinic)

Donor Natural Killer Cell Therapy and Aldesleukin in Treating Patients With High Risk Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant -- Sara Cooley, MD (University of Minnesota Medical School) -- Now solely located at University of Minnesota PACT facility

Human MSC Master Cell Bank - Peiman Hematti, MD (UW-Madison, UWHC)

cGMP Production of WA01 hESC Master Cell Bank - Derek Hei, PhD (Waisman Biomanufacturing, UW-Madison)

Safety and Efficacy of a Double Dose Strategy of Bone Marrow-derived MSC Infusion And Transendocardial Injection In A Swine Myocardial Infarction-- Amish Raval, MD (UW-Madison, UWHC)

MSC/Gel formulation for Vocal Fold Repair -- Susan Thibeault (UW-Madison, UWHC)

MSC Immuno-Potency Assays - Peiman Hematti, MD and Debra Bloom, PhD (UW-Madison, UWHC)

For additional information specific to PACT, please visit their website: www.pactgroup.net